Publications

Publications (full papers and review articles)

Resulting directly, or in part from Euroclast funded research

ESR names in bold. In order of most recent publication date.

  1. Segeletz, S. & Hoflack., B. (2018) Mass Spectrometry peoreomics in osteoblast and osteoclast biology. Encyclopedia of bone biology. in press.
  2. Segeletz, S., Langlot, L., Galli., T. & Hoflack., B. (2018) ARAP1 bridges actin dynamics and AP-3-dependent membrane traffic in bone digesting osteoclasts. iScience. DOI: 10.1016/j.isci.2018.07.019
  3. Gustafsson, K.L., Nilsson, K.H., .Farman, H.H., Andersson, A., Lionikaite, V., Henning, P., Wu, J., Windahl, S.H., Islander, U., Movérare-Skrtic, S., Sjögren, K., Carlsten, H., Gustafsson, J.Å., Ohlsson, C., & Lagerquist, M.K. (2018) ERα expression in T lymphocytes is dispensable for estrogenic effects in bone. J Endocrinol. 238(2):129-136. DOI: 10.1530/JOE-18-0183. Epub 2018 May 30.
  4. Löfvall, H., Newbould, H., Karsdal, M.A., Dziegiel, M.H., Richter, J., Henriksen, K., & Thudium, C. S. (2018) Osteoclasts degrade bone and cartilage knee joint compartments through different resorption processes. Arthritis Res Ther. 20(1), 67. DOI: 10.1186/s13075-018-1564-5.
  5. Moscatelli, I., Löfvall, H., Schneider Thudium, C., Rothe, M., Montano, C., Kertész, Z., Sirin, M., Schulz, A., Schambach, A., Henriksen,K., & Richter, J. (2017) Targeting NSG Mice Engrafting Cells with a Clinically Applicable Lentiviral Vector Corrects Osteoclasts in Infantile Malignant Osteopetrosis. J. Hum Gene Ther. Oct 3. DOI: 10.1089/hum.2017.053. [Epub ahead of print]
  6. Luukonen, J., Pascual, L.M., Patlaka, C., Lång, P., Turunen, S., Halleen, J., Nousiainen, T., Valkealahti, M., Tuukanen, J., Andersson, G., & Lehenkari, P. (2017).  Increased amount of phosphorylated proinflammatory osteopontin in rheumatoid arthritis synovia is associated to decreased tartrate-resistant acid phosphatase 5B/5A ratio. PLoS One. Aug 8; 12(8):e0182904. DOI: 10.1371/journal.pone.0182904
  7. Stattin, E.L, Henning, P., Klar, J., McDermott, E., Stecksen-Blicks, C., Sandström, P.E., Kellgren, T.G, Rydén, P., Hallmans, G., Lönnerholm, T., Ameur, A., Helfrich, M., Coxon, F., Dahl, N., Wikström, J., & Lerner, U.H. (2017). SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclasts. Scientific reports. 7, 3012. DOI: 10.1038/s41598-017-02533-2
  8. Montano Almendras, C.P., Thudium, C.S., Löfvall, H., Moscatelli, I., Schambach, A., Henriksen, K., & Richter, J. (2017), Forced expression of human M-CSF in CD34+ cells promotes monocyte differentiation in vitro and in vivo but blunts osteoclastogenesis in vitro. Eur. J. Haematol. Accepted Author Manuscript. DOI:10.1111/ejh.12867
  9. Cao Y., Jansen, I.D.C., Sprangers, S., de Vries, T.J., & Everts, V. (2017) TNF-α has both stimulatory and inhibitory effects on mouse monocyte-derived osteoclastogenesis. J Cell Physiol. 232:3273-3285 DOI: 10.1002/jcp.26024. 
  10. Cao, Y., Wang, Y., Sprangers, S., Picavet, D.I., Glogauer, M., McCulloch, C.A., & Everts, V. (2017) Deletion of adseverin in osteoclasts affects cell structure but not bone metabolism. Calcif Tissue Int. 101:207-216. DOI: 10.1007/s00223-017-0271-6 
  11. Sprangers, S., Behrendt, N., Engelholm, L., Cao, Y., & Everts, V. (2017) Phagocytosis of collagen fibrils by fibroblasts in vivo is independent of the uPARAP/Endo180 receptor. J. Cell. Biochem. 118:1590-1595. DOI 10.1002/jcb25821 
  12. Sprangers, S., Schoenmaker, T., Cao, Y., Everts, V., & de Vries, T.J. (2017) Integrin αMβ2 is differently expressed by subsets of human osteoclast precursors and mediates adhesion of classical monocytes to bone. Exp. Cell Res. 350:161-168.   DOI: 10.1016/j.yexcr.2016.11.018
  13. Di Ceglie, I., van den Akker, G.G., Ascone, G., Ten Harkel B., Häcker, H., van de Loo, F.A., Koenders, M.I., van der Kraan, P.M., de Vries, T.J., Vogl, T., Roth, J., & van Lent, P.L. (2016) Genetic modification of ER-Hoxb8 osteoclast precursors using CRISPR/Cas9 as a novel way to allow studies on osteoclast biology. J. Leukoc. Biol. Dec 5. [Epub ahead of print] DOI: 10.1189/jlb.1AB0416-180RR
  14. Sztacho, M., Segeletz, S., Sanchez-Fernandez, M.A., Czupalla, C., Niehage, C., & Hoflack, B. (2016) BAR Proteins PSTPIP1/2 regulate podosome dynamics and the resorption activity of osteoclasts. PLoS One. 11(10):e0164829. DOI: 10.1371/journal.pone.0164829
  15. Cao, Y., Jansen, I.D.C., Sprangers, S., Stap, J., Leenen, P.J.M., Everts, V., & de Vries, T.J. (2016) IL-1β differently stimulates proliferation and multiucleation of distinct mouse bone marrow osteoclast precursor subsets. J. Leukoc. Biol. 100:513-523. DOI: 10.1189/jlb.1A1215-543R 
  16. Thudium, C.S., Moscatelli, I., Löfvall, H., Kertész, Z., Montano, C., Bjurström, C.F., Karsdal, M.A., Schulz, A., Richter, J., & Henriksen, K. (2016) Regulation and function of lentiviral vector-mediated TCIRG1 expression in osteoclasts from patients with infantile malignant osteopetrosis: implications for gene therapy. Calcif. Tissue Int. 99:638-648. DOI: 10.1007/s00223-016-0187-6  
  17. Segeletz, S., & Hoflack, B. (2016) Proteomic approaches to study osteoclast biology. Proteomics 16:2545-2556. DOI: 10.1002/pmic.201500519  
  18. Sprangers, S., De Vries, T.J., & Everts, V. (2016) Monocyte heterogeneity: consequences for monocyte-derived immune cells. J. Immunol. Res. Article ID 1475435, 10 pg DOI: 10.1155/2016/1475435 
  19. Gustafsson, K.L., Farman, H., Henning, P., Lionikaite, V., Movérare-Skrtic, S., Wu, J., Ryberg, H., Koskela, A., Gustafsson, J.Å., Tuukkanen, J., Levin, E.R., Ohlsson, C, & Lagerquist, M.K. (2016) The role of membrane ERα signaling in bone and other major estrogen responsive tissues. Sci Rep. 8, 6:29473. DOI: 10.1038/srep29473.
  20. Sprangers, S., Schoenmaker, T., Cao, Y., Everts, V., & de Vries, T.J. (2015) Different blood-borne human osteoclast precursors respond in distinct ways to IL-17A. J. Cell. Physiol. 231:1249-1260. DOI: 10.1002/jcp.25220
  21. Gustafsson, K.L., Nilsson, K.H., .Farman, H.H., Andersson, A., Lionikaite, V., Henning, P., Wu, J., Windahl, S.H., Islander, U., Movérare-Skrtic, S., Sjögren, K., Carlsten, H., Gustafsson, J.Å., Ohlsson, C., & Lagerquist, M.K. (2018) ERα expression in T lymphocytes is dispensable for estrogenic effects in bone. J Endocrinol. 238(2):129-136. DOI: 10.1530/JOE-18-0183. Epub 2018 May 30.
  22. Löfvall, H., Newbould, H., Karsdal, M.A., Dziegiel, M.H., Richter, J., Henriksen, K., & Thudium, C. S. (2018) Osteoclasts degrade bone and cartilage knee joint compartments through different resorption processes. Arthritis Res Ther. 20(1), 67. DOI: 10.1186/s13075-018-1564-5.
  23. Moscatelli, I., Löfvall, H., Schneider Thudium, C., Rothe, M., Montano, C., Kertész, Z., Sirin, M., Schulz, A., Schambach, A., Henriksen,K., & Richter, J. (2017) Targeting NSG Mice Engrafting Cells with a Clinically Applicable Lentiviral Vector Corrects Osteoclasts in Infantile Malignant Osteopetrosis. J. Hum Gene Ther. Oct 3. DOI: 10.1089/hum.2017.053. [Epub ahead of print]
  24. Luukonen, J., Pascual, L.M., Patlaka, C., Lång, P., Turunen, S., Halleen, J., Nousiainen, T., Valkealahti, M., Tuukanen, J., Andersson, G., & Lehenkari, P. (2017).  Increased amount of phosphorylated proinflammatory osteopontin in rheumatoid arthritis synovia is associated to decreased tartrate-resistant acid phosphatase 5B/5A ratio. PLoS One. Aug 8; 12(8):e0182904. DOI: 10.1371/journal.pone.0182904
  25. Stattin, E.L, Henning, P., Klar, J., McDermott, E., Stecksen-Blicks, C., Sandström, P.E., Kellgren, T.G, Rydén, P., Hallmans, G., Lönnerholm, T., Ameur, A., Helfrich, M., Coxon, F., Dahl, N., Wikström, J., & Lerner, U.H. (2017). SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclasts. Scientific reports. 7, 3012. DOI: 10.1038/s41598-017-02533-2
  26. Montano Almendras, C.P., Thudium, C.S., Löfvall, H., Moscatelli, I., Schambach, A., Henriksen, K., & Richter, J. (2017), Forced expression of human M-CSF in CD34+ cells promotes monocyte differentiation in vitro and in vivo but blunts osteoclastogenesis in vitro. Eur. J. Haematol. Accepted Author Manuscript. DOI:10.1111/ejh.12867
  27. Cao Y., Jansen, I.D.C., Sprangers, S., de Vries, T.J., & Everts, V. (2017) TNF-α has both stimulatory and inhibitory effects on mouse monocyte-derived osteoclastogenesis. J Cell Physiol. 232:3273-3285 DOI: 10.1002/jcp.26024. 
  28. Cao, Y., Wang, Y., Sprangers, S., Picavet, D.I., Glogauer, M., McCulloch, C.A., & Everts, V. (2017) Deletion of adseverin in osteoclasts affects cell structure but not bone metabolism. Calcif Tissue Int. 101:207-216. DOI: 10.1007/s00223-017-0271-6 
  29. Sprangers, S., Behrendt, N., Engelholm, L., Cao, Y., & Everts, V. (2017) Phagocytosis of collagen fibrils by fibroblasts in vivo is independent of the uPARAP/Endo180 receptor. J. Cell. Biochem. 118:1590-1595. DOI 10.1002/jcb25821 
  30. Sprangers, S., Schoenmaker, T., Cao, Y., Everts, V., & de Vries, T.J. (2017) Integrin αMβ2 is differently expressed by subsets of human osteoclast precursors and mediates adhesion of classical monocytes to bone. Exp. Cell Res. 350:161-168.  DOI: 10.1016/j.yexcr.2016.11.018
  31. Di Ceglie, I., van den Akker, G.G., Ascone, G., Ten Harkel B., Häcker, H., van de Loo, F.A., Koenders, M.I., van der Kraan, P.M., de Vries, T.J., Vogl, T., Roth, J., & van Lent, P.L. (2016) Genetic modification of ER-Hoxb8 osteoclast precursors using CRISPR/Cas9 as a novel way to allow studies on osteoclast biology. J. Leukoc. Biol. Dec 5. [Epub ahead of print] DOI: 10.1189/jlb.1AB0416-180RR
  32. Sztacho, M., Segeletz, S., Sanchez-Fernandez, M.A., Czupalla, C., Niehage, C., & Hoflack, B. (2016) BAR Proteins PSTPIP1/2 regulate podosome dynamics and the resorption activity of osteoclasts. PLoS One. 11(10):e0164829. DOI: 10.1371/journal.pone.0164829
  33. Cao, Y., Jansen, I.D.C., Sprangers, S., Stap, J., Leenen, P.J.M., Everts, V., & de Vries, T.J. (2016) IL-1β differently stimulates proliferation and multiucleation of distinct mouse bone marrow osteoclast precursor subsets. J. Leukoc. Biol. 100:513-523. DOI: 10.1189/jlb.1A1215-543R 
  34. Thudium, C.S., Moscatelli, I., Löfvall, H., Kertész, Z., Montano, C., Bjurström, C.F., Karsdal, M.A., Schulz, A., Richter, J., & Henriksen, K. (2016) Regulation and function of lentiviral vector-mediated TCIRG1 expression in osteoclasts from patients with infantile malignant osteopetrosis: implications for gene therapy. Calcif. Tissue Int. 99:638-648. DOI: 10.1007/s00223-016-0187-6  
  35. Segeletz, S., & Hoflack, B. (2016) Proteomic approaches to study osteoclast biology. Proteomics 16:2545-2556. DOI: 10.1002/pmic.201500519  
  36. Sprangers, S., De Vries, T.J., & Everts, V. (2016) Monocyte heterogeneity: consequences for monocyte-derived immune cells. J. Immunol. Res. Article ID 1475435, 10 pg DOI: 10.1155/2016/1475435 
  37. Gustafsson, K.L., Farman, H., Henning, P., Lionikaite, V., Movérare-Skrtic, S., Wu, J., Ryberg, H., Koskela, A., Gustafsson, J.Å., Tuukkanen, J., Levin, E.R., Ohlsson, C, & Lagerquist, M.K. (2016) The role of membrane ERα signaling in bone and other major estrogen responsive tissues. Sci Rep. 8, 6:29473. DOI: 10.1038/srep29473.
  38. Sprangers, S., Schoenmaker, T., Cao, Y., Everts, V., & de Vries, T.J. (2015) Different blood-borne human osteoclast precursors respond in distinct ways to IL-17A. J. Cell. Physiol. 231:1249-1260. DOI: 10.1002/jcp.25220

Other papers (not Euroclast-funded) to which Euroclast ESRs contributed

  1. Di Ceglie, I., Ascone, G, Cremers, N.A.J., Sloetjes, A.W., Walgreen, B., Vogl, T., Roth, J., Verbeek, J.S., van de Loo, F.A.J., Koenders, M.I., van der Kraan, P.M., Blom, A.B., van den Bosch, M.H.J., van Lent, P.L.E.M. (2018) Fcγ receptor-mediated influx of S100A8/A9-producing neutrophils as inducer of bone erosion during antigen-induced arthritis. Arthritis Res Ther. 20(1):80. DOI: 10.1186/s13075-018-1584-1.
  2. Lokau, J., Göttert, S., Arnold, P., Düsterhöft, S., Massa López, D., & Grötzinger, J., Garbers C. (2018) The SNP rs4252548 (R112H) which is associated with reduced human height compromises the stability of IL-11. Biochim Biophys Acta. 1865:496-506. DOI: 10.1016/j.bbamcr.2017.12.003. 
  3. Sprangers, S., & Everts V. (2017) Molecular pathways of cell-mediated degradation of fibrillar collagen. Matrix Biol. Corrected proof online Nov 20. DOI: 10.1016/j.matbio.2017.11.008. 
  4. Cremers, N.A.J., van den Bosch, M.H.J., van Dalen, S., Di Ceglie, I., Ascone, G, van de Loo, F., Koenders, M., van der Kraan, P., Sloetjes, A., Vogl, T., Roth, J., Geven, E.J.W., Blom, A.B., van Lent, P.L.E.M. (2017) Arthritis Res Ther. 19:217. DOI: 10.1186/s13075-017-1426-6.
  5. Geven, E.J., van den Bosch, M.H., Di Ceglie, I., Ascone, G., Abdollahi-Roodsaz, S., Sloetjes, A.W., Hermann, S., Schäfers, M., van de Loo, F.A., van der Kraan, P.M., Koenders, M.I., Foell, D., Roth, J., Vogl, T., & van Lent, P.L. (2016) S100A8/A9, a potent serum and molecular imaging biomarker for synovial inflammation and joint destruction in seronegative experimental arthritis. Arthr. Res. Ther. 18: 24. DOI: 10.1186/s13075-016-1121-z

 

 

 

Conference presentations

Conference presentations aat the European Calcified Tissue Society meetings in 2015 and 2016 and the ECTS PhD training course in 2015

Euroclast held a consortium meeting in Rome, prior to attending the conference of the European Calcified Tissue Society 2016.

All ESRs presented at the ECTS consortia summit and again during the conference.

  1. Vikte Lionikaite, Karin Gustafsson, Anna Westerlund, Antti Koskela, Juha Tukkanen, H. Herschel Conaway, Claes Ohlsson, Petra Henning & Ulf Lerner. Effects of Clinically Relevant Doses of Vitamin A on Bone in Mice. Bone Abstracts (2016) 5 P280.DOI:10.1530/boneabs.5.P280
  2. Henrik Löfvall, Christian Schneider Thudium, Ilana Moscatelli, Carmen Montano, Ansgar Schulz, Johan Richter & Kim Henriksen. Regulation and function of lentiviral-mediated TCIRG1 expression in osteoclasts from infantile malignant osteopetrosis patients. Bone Abstracts (2016) 5 P192. DOI:10.1530/boneabs.5.P192
  3. Giuliana Ascone, Irene Di Ceglie, Wouter de Munter, Birgitte Walgreen, Annet Sloetjes & Peter van Lent. Apolipoprotein E aggravates inflammation and bone destruction in murine antigen - induced arthritis. Bone Abstracts (2016) 5 P9.DOI:10.1530/boneabs.5.P9
  4. Emma McDermott, David Sunderhauf, Kevin Mackenzie, Debbie Wilkinson & Miep Helfrich. Identification and characterisation of vesicles in resorbing osteoclasts using electron tomography. Bone Abstracts 5 P190. www.bone-abstracts.org/ba/0005/ba0005p190.htm  DOI:10.1530/boneabs.5.P190
  5. Anh Tran, Fraser Coxon, Emma McDermott, Ian Ganley, Paul Odgren, Jennifer Martinez, Douglas Green & Miep Helfrich. The role of LC3 and autophagy in bone resorption by osteoclasts. Bone Abstracts (2016) 5 P195. 
  6. DOI:10.1530/boneabs.5.P195
  7. David Massa Lopez, Markus Damme & Paul Saftig. Characterising the role of the lysosomal membrane proteins MFSD1 and TMEM106b in osteoclasts. Bone Abstracts (2016) 5 P185. DOI:10.1530/boneabs.5.P185
  8. Sara Sprangers, Ton Schoenmaker, Yixuan Cao, Vincent Everts & Teun J. de Vries. Involvement of integrin Beta 2/CD18 in attachment of monocytes to bone. Bone A(2016)bstracts (2016) 5 P184. DOI:10.1530/boneabs.5.P184
  9. Yixuan Cao, Ineke Jansen, Sara Sprangers, Jan Stap, Vincent Everts & Teun de Vries. Life span differs between osteoclasts derived from different bone marrow precursors : a time-lapse microscopy study. Bone Abstracts (2016) 5 P183.   DOI:10.1530/boneabs.5.P183
  10. Sandra Segeletz, & Bernard Hoflack. The Arf and Rho GTPase-activating protein (GAP) ARAP1 regulates osteoclast function. Bone Abstracts (2016) 5 P188. DOI:10.1530/boneabs.5.P188
  11. Laia Mira Pascual, Pernilla Lång & Göran Andersson, RAW264.7 subclones – an in vitro model for osteoclast heterogeneity? Bone Abstracts (2016) 5 P200. DOI:10.1530/boneabs.5.P200
  12. Christina Patlaka, Laia Mira-Pascual, Staffan Paulie, Pernilla Lång & Göran Andersson. Development of a novel sandwich ELISA to quantify human Tartrate Resistant Acid Phosphatase (TRAP) isoforms 5a and 5b protein in one and the same sample. Bone Abstracts (2016) 5 P198. DOI:10.1530/boneabs.5.P198

A number of Euroclast ESRs presented their projects at the conference of the European Calcified Tissue Society in Rotterdam in April 2015. During this meeting Euroclast also presented a consortium poster highlighting all the research projects and training activities undertaken by its ESRs

  1. Laia Mira Pascual, Christina Patlaka, Pernilla Lång & Göran Andersson.  Tartrate resistant acid phosphatase 5a – a coupling factor between osteoclast and osteoclast with potential growth factor activity? Article number: 673 (2015) P204.DOI:1.1038/bonekey.2015.40
  2. Sara Sprangers, Ton Schoemaker, Yixuan Cao, Vincent Everts & Teun de Vries. Different human osteoclast precursors respond in distinct ways to IL-17A.  IBMS BoneKEy 13. Article number: 673 (2015) P211. DOI:1.1038/bonekey.2015.40
  3. Yixuan Cao, Ineke Jansen, Sara Sprangers, Vincent Everts & Teun de Vries. IL1-β differently affects osteoclastogenesis of distinct subsets of osteoclast precursors.  IBMS BoneKEy 13. Article number: 673 (2015) P212. DOI:1.1038/bonekey.2015.40

Several Euroclast ESRs attended the ECTS PhD training course in Siena, Italy, September 2015 and presented their work.

  1. Emma McDermott, Kevin Mackenzie, Fraser Coxon, & Miep Helfrich. Characterisation of osteoclast vesicular compartment and ruffled border ultrastructure using advanced imaging. Poster presentation.
  2. Vikte Lionikaite. The role of retinoids in bone remodelling. Oral Presentation.
  3. David Massa Lopez, Emma McDermott, Paul Saftig, & Markus Damme. CD63 is implicated in differentiation of osteoclasts during stimulation with MCSF and RANKL. Poster presentation.
  4. Sandra Segeletz, & Bernard Hoflack, Coupling post Golgi transport with membrane dynamics in osteoclasts.  Oral presention
  5. Sara Sprangers, Ton Schoenmaker, Yixuan Cao, Vincent Everts, & Teun J. de Vries. Different human osteoclast precursors respond in distinct ways to IL-17A. Poster presentation.
  6. Yixuan Cao, Ineke Jansen, Sara Sprangers, Vincent Everts, & Teun de Vries. IL1-β differently affects osteoclastogenesis of distinct subsets of osteoclast precursors.  Poster presentation.
  7. Anh Tran. Mechanisms/Molecules Essential in Ruffled Border Formation:  Focus on Autophagy.  Oral presentation.
  8. Arjen Gebraad, Teuvo Hentunen, Tiina Laitala-Leinonen.  Retrieval of Resorptive Osteoclasts from Temperature-Responsive Plastic. Poster presentation.

Selected presentations at other international meetings

  1. Anh Tran, Sandra Segeletz, Emma McDermott, Justin Rochford, Tom Wileman & Miep Helfrich. The role of canonical and non-canonical autophagy in bone resorption by osteoclasts. Bone Research Society meeting in Winchester, UK June 2018. Poster presentation.
  2. Anh Tran, Emma McDermott, Justin Rochford & Miep Helfrich. Pleckstrin homology domain containing protein family member 1 (PLEKHM1) regulates bone resorption through sealing zone dynamics and lysosomal targeting in osteoclasts. Bone Research Society meeting in Winchester, UK June 2018. Poster presentation.
  3. Anh Tran, Sandra Segeletz, Emma McDermott, Justin J Rochford & Miep Helfrich. The role of canonical and non-canonical autophagy in bone resorption by osteoclasts. Americal Society for Cell Biology annual meeting. Dec. 2017. Poster presentation.
  4. Lionikaite V, Westerlund A, Conaway HH, Lerner UH, and Henning P.Effects of Retinoids on Physiological and Inflammatory Osteoclastogenesis in vitro. American Society for Bone and Mineral Research (ASBMR) Annual Meeting 2017. Poster presentation.
  5. Emma McDermott, Anh Tran, Debbie Wilkinson, Kevin MacKenzie, Justin Rochford & Miep Helfrich. Osteoclast ruffled border formation: a new perspective. Bone Research Society meeting in Bristol, UK 25-27 June 2017, oral presentation. J Musculoskelet Neuronal Interact (2018); 18:111, https://www.ncbi.nlm.nih.gov/pubmed/29504586
  6. Emma McDermott, Anh Tran, Debbie Wilkinson, Kevin Mackenzie, Justin Rochford & Miep Helfrich’ Understanding osteoclast ruffled border formation using electron tomography and live cell imaging’ MMC in Manchester 3-6 July 2017, Celtic Sessions, oral presentation.  https://www5.shocklogic.com/scripts/jmevent/programme.php?client_Id=RMS&project_Id=MMC2017
  7. Ascone G., DiCeglie I., de Munter W., Walgreen B., Sloetjes A., van der Kraan P., Lindhout E., Martens M., van Lent P. Apolipoprotein E Stimulates Inflammation And Joint Destruction During Antigen-Induced Arthritis (AIA).European Workshop for Rheumatology Research 2017 (EWRR).  Conference Paper. Annals of the Rheumatic Diseases 76 (Suppl 1): A34.1-A34. DOI:10.1136/annrheumdis-2016-211049.11
  8. Ascone G, Di Ceglie I, de Munter W, Walgreen B, Sloetjes A, van der Kraan PM, Lindhout E, Martens M, & van Lent PLEM. Apolipoprotein E Regulates Inflammation and Joint Destruction during Antigen-Induced Arthritis (AIA). Arthritis Rheumatol. 2016; 68 (suppl 10). 
  9. Ascone, G., Di Ceglie, I., de Munter, W., Walgreen, B., Sloetjes, A.,  van Lent, P., & van der Kraan, P. Apolipoprotein E aggravates inflammation and bone destruction in murine antigen - induced arthritis. European League Against Rheumatism, London, 2016. Oral presentation.  Ann. Rheum. Dis. 2016; 75 (Suppl.2):136
  10. Massa López, D., Lüllmann-Rauch, R., Saftig, P. & Damme M.(2015) Characterization of MFSD1-a new lysosomal protein- and its physiological role in the mouse. European Study Group on Lysosomal Diseases (ESGLD). https://www.esgld.org/past-esgld-workshops/ P57
  11. Ascone G., Di Ceglie I., van den Bosch M., Sloetjes A., van der Kraan P., Lindhout E., Blom A.,van Lent P.. High Cholesterol Levels By ApoE Deficiency Reduce Bone Destruction in Antigen-Induced Arthritis Via Reduction Of The Number Of Osteoclasts. European Workshop for Rheumatology Research 2017 (EWRR).  Conference Paper. http://dx.doi.org/10.1136/annrheumdis-2018-EWRR2018.69

Selected presentations at national meetings

  1. Emma McDermott, Debbie Wilkinson, Kevin Mackenzie, Justin Rochford, & Miep Helfrich (2016) Visualising osteoclast ruffled border formation using electron tomography. Scottish Microscopy Group Meeting Edinburgh. http://scottishmicroscopygroup.org.uk/symposia/2016-symposium Poster presentation.
  2. Sara Sprangers, Yolande Ramos, Ton Schoenmaker, Yixuan Cao, Vincent Everts, Ingrid Meulenbelt, & Teun J. de Vries. Patients with OA due to a gain-of-function OPG mutation have affected osteoclastogenesis. Nederlandse Vereniging voor Calcium- en Botstofwisseling 2016. Oral presentation (SS). http://www.nvcb.nl/files//NVCB%20Program%202016%20laatste%20versie%20(kort).pdf
  3. Yixuan Cao, Ineke Jansen, Sara Sprangers, Teun J. de Vries, & Vincent Everts (2016) TNF-α prevents osteoclast formation by mouse monocytes due to interfering with RANKL- RANK interaction. Nederlandse Vereniging voor Calcium- en Botstofwisseling 2016. Oral presentation (YC). http://www.nvcb.nl/files//NVCB%20Program%202016%20laatste%20versie%20(kort).pdf
  4. David Sünderhauf, Emma McDermott, Debbie Wilkinson, Kevin Mackenzie, & Miep Helfrich. Identification and characterisation of extracellular vesicles and uptake events in resorbing osteoclasts using electron tomography. 2016. Poster pitching (DS) and poster presentation.  http://www.frontiersin.org/books/Bone_Research_Society_Annual_Meeting_2016/1006 P50.
  5. Anh Tran, Fraser Coxon, Emma McDermott, Angela Douglass, Diana Miranda de Stegmann, Ian Ganley, Paul Odgren, Wim van Hul, & Miep Helfrich (2016) The role of LC3 and autophagy in bone resorption by osteoclasts. The 2nd Autophagy UK meeting. Edinburgh.  http://autophagy.uk/meeting2016/ Oral presentation (AT).
  6. Sara Sprangers, Ton Schoenmaker, Yixuan Cao, Vincent Everts, & Teun J. de Vries. Interaction between different osteoclast precursors and bone. Nederlandse Vereniging voor Calcium- en Botstofwisseling 2015. Oral presentation (SS). Awarded with the presentation price. 
  7. Yixuan Cao, Ineke Jansen, Sara Sprangers, Jan Stap, Vincent Everts & Teun J. de Vries. A diverse stimulatory role of IL-1β on different murine osteoclast precursor subsets: a microscopy study. Nederlandse Vereniging voor Calcium- en Botstofwisseling 2015. Oral presentation (YC).
  8. Sara Sprangers, Ton Schoenmaker, Yixuan Cao, Vincent Everts, & Teun J. de Vries Different human osteoclast precursors respond in distinct ways to IL-17A. Nederlandse Vereniging voor Calcium- en Botstofwisseling 2014. Oral presentation (SS).
  9. Yixuan Cao, Ineke Jansen, Sara Sprangers, Vincent Everts, & Teun J. de Vries. IL-1beta differently affects osteoclastogenesis of distinct osteoclast precursor subsets. Nederlandse Vereniging voor Calcium-en Botstofwisseling 2014. Oral presentation (YC).

 

Public outreach

See also the webpages of Euroclast for more information about public outreach.

  1. Emma McDermott. Winner of 2nd prize in the Imaging Competition of the Scottish Microscopy Group 2016. http://scottishmicroscopygroup.org.uk/smg-image-competition.
  2. David Massa Lopez, Markus Damme and Paul Saftig. European Researchers Night, 30th September 2016,Leibnizstraße, Christian-Albrechts-Universität zu Kiel. Presentation of “Euroclast” poster.
  3. Yixuan Cao, Teun de Vries, Ineke Jansen. Vrije University Amsterdam anniversary event “Kowledge in movement”. Organization of workshop “Long live bone”, 16/04/2016, Amsterdam. http://www.euroclast.eu/documents/Euroclast_Newsletter_VU_openday.pdf
  4. Emma Mc Dermott, Anh Tran, Miep Helfrich and Fraser Coxon. European Researchers Night, 25th September 2015, Union Square Shopping Centre, Aberdeen. Stand and “science busking” to promote bone health and the work done by the Euroclast consortium. http://www.euroclast.eu/about/outreach/
  5. Emma Mc Dermott. Euroclast, understanding the Osteoclast. Paper in AU magazine.  http://ausm.org.uk/wp content/uploads/2014/02/Issue11.pdf

 

PhD thesis titles and completion dates

ACTA/VUMC
Sara Sprangers:

Monocyte Heterogeneity and the formation of Functionally Distinct Osteoclasts. Succesfully defended June 28th, 2017
Yixuan Cao:
The Diversity of Osteoclast precursors and Their Responses to Inflammatory Cytokines. Succesfully defended November 29th, 2017.

TUD
Sandra Segeletz
:
Regulation of the AP-3 dependent transport and actin dynamics through ARAP1. Succesfully defended June 28, 2017

UGOT
Vikte Lionikaite:

Heterogeneity in osteoclast formation and proteolytic enzymes in retinoid treated mice. Defense planned for Autumn 2018

CAU
David Massa Lopez

MFSD1 characterization and study of MFSD1 KO mouse model. Late summer, 2018.

NB
Henrik Löfvall

Development of novel therapies, models and biomarkers for osteoclast-related diseases. Defense scheduled for Oct 26 2018.

UNIABDN
Emma McDermott:

Characterisation of the osteoclast ruffled border using advanced imaging techniques. Successfully defended March 22, 2018
Anh Tran:
Examining the role of autophagy in osteoclast function, Successfully defended June 15, 2018

KI
Laia Mira Pascal:

Preliminary title is: Tartrate resistant acid phosphatase isoforms in bone remodeling. ESR Laia Mira Pascal will defend her half time control on August 24th 2018. She will then defend her thesis during the period 13-19th of December 2019, exact date will be decided in the application which will be submitted late August 2019.

RadboudUMC/FDS
Giuliana Ascone:

Preliminary title of the thesis: The effects of high cholesterol on myeloid cells in rheumatic diseases. Defense will be in 2019, date to be agreed.

University of Turku
ESR changeover in last year of project. PhD thesis title and defense date not yet agreed.

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